Constitutive nitric oxide synthase gene polymorphisms and house dust mite respiratory allergy in an Algerian patient group
Identifieur interne : 000563 ( Main/Exploration ); précédent : 000562; suivant : 000564Constitutive nitric oxide synthase gene polymorphisms and house dust mite respiratory allergy in an Algerian patient group
Auteurs : R. Djidjik [Algérie] ; M. Ghaffor [Algérie] ; M. Brun [France] ; M. Gharnaout [Algérie] ; S. S. Salah [Algérie] ; W. Boukouaci [France] ; H. Djidjik [Algérie] ; A. Benyounes [Algérie] ; K. Koumaravelou [France] ; R. Krishnamoorthy [France] ; M. C. Abbadi [Algérie] ; D. Charron [France] ; R. Tamouza [France]Source :
- Tissue Antigens [ 0001-2815 ] ; 2008-02.
Descripteurs français
- Wicri :
- topic : Afrique du Nord.
English descriptors
- KwdEn :
Abstract
Genetic polymorphisms in neuronal nitric oxide synthase (NOS1) and calmodulin‐dependent endothelial NOS (NOS3) genes are known to influence the course of allergic respiratory disorders. We investigated the role of NOS1 −84 G→A and NOS3 −786 T→C, 894 G→T and 27 base pair (bp) repeat polymorphisms in 125 patients suffering from asthma and/or rhinitis and monosensitized against Dermatophagoides pteronyssinus (Dpter) and 111 controls from Algeria. We found a higher frequency of the −786 C NOS3 allele in patients than in controls [corrected P value (Pc) = 0.04], especially in female cases (Pc = 0.02) and that the ‘ab’ genotype of the 27‐bp polymorphism was significantly associated with specific immunoglobulin E production against Dpter (P = 0.006). This study brings further support for the participation of NOS3 gene polymorphism in the pathogenesis of respiratory allergic disorders.
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DOI: 10.1111/j.1399-0039.2007.00976.x
Affiliations:
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Tamouza</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire d’Immunologie et d’Histocompatibilité AP‐HP, IUH, CIB‐HOG et INSERM, U662, Hôpital Saint Louis, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="1"><country wicri:rule="url">France</country></affiliation></author></analytic><monogr></monogr><series><title level="j">Tissue Antigens</title><idno type="ISSN">0001-2815</idno><idno type="eISSN">1399-0039</idno><imprint><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2008-02">2008-02</date><biblScope unit="volume">71</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="160">160</biblScope><biblScope unit="page" to="164">164</biblScope></imprint><idno type="ISSN">0001-2815</idno></series><idno type="istex">0C11EADB6526BBA96EAA205404475C2BF1C2AA18</idno><idno type="DOI">10.1111/j.1399-0039.2007.00976.x</idno><idno type="ArticleID">TAN976</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0001-2815</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>North Africa</term><term>asthma</term><term>immunoglobulin E‐mediated respiratory allergy</term><term>nitric oxide</term><term>nitric oxide synthase genes</term><term>polymorphism</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Afrique du Nord</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Genetic polymorphisms in neuronal nitric oxide synthase (NOS1) and calmodulin‐dependent endothelial NOS (NOS3) genes are known to influence the course of allergic respiratory disorders. We investigated the role of NOS1 −84 G→A and NOS3 −786 T→C, 894 G→T and 27 base pair (bp) repeat polymorphisms in 125 patients suffering from asthma and/or rhinitis and monosensitized against Dermatophagoides pteronyssinus (Dpter) and 111 controls from Algeria. We found a higher frequency of the −786 C NOS3 allele in patients than in controls [corrected P value (Pc) = 0.04], especially in female cases (Pc = 0.02) and that the ‘ab’ genotype of the 27‐bp polymorphism was significantly associated with specific immunoglobulin E production against Dpter (P = 0.006). This study brings further support for the participation of NOS3 gene polymorphism in the pathogenesis of respiratory allergic disorders.</div></front></TEI><affiliations><list><country><li>Algérie</li><li>France</li></country><region><li>Wilaya d'Alger</li><li>Île-de-France</li></region><settlement><li>Alger</li><li>Paris</li></settlement></list><tree><country name="Algérie"><region name="Wilaya d'Alger"><name sortKey="Djidjik, R" sort="Djidjik, R" uniqKey="Djidjik R" first="R." last="Djidjik">R. Djidjik</name></region><name sortKey="Abbadi, M C" sort="Abbadi, M C" uniqKey="Abbadi M" first="M. C." last="Abbadi">M. C. Abbadi</name><name sortKey="Benyounes, A" sort="Benyounes, A" uniqKey="Benyounes A" first="A." last="Benyounes">A. Benyounes</name><name sortKey="Djidjik, H" sort="Djidjik, H" uniqKey="Djidjik H" first="H." last="Djidjik">H. Djidjik</name><name sortKey="Ghaffor, M" sort="Ghaffor, M" uniqKey="Ghaffor M" first="M." last="Ghaffor">M. Ghaffor</name><name sortKey="Gharnaout, M" sort="Gharnaout, M" uniqKey="Gharnaout M" first="M." last="Gharnaout">M. Gharnaout</name><name sortKey="Salah, S S" sort="Salah, S S" uniqKey="Salah S" first="S. S." last="Salah">S. S. Salah</name></country><country name="France"><region name="Île-de-France"><name sortKey="Brun, M" sort="Brun, M" uniqKey="Brun M" first="M." last="Brun">M. Brun</name></region><name sortKey="Boukouaci, W" sort="Boukouaci, W" uniqKey="Boukouaci W" first="W." last="Boukouaci">W. Boukouaci</name><name sortKey="Charron, D" sort="Charron, D" uniqKey="Charron D" first="D." last="Charron">D. Charron</name><name sortKey="Koumaravelou, K" sort="Koumaravelou, K" uniqKey="Koumaravelou K" first="K." last="Koumaravelou">K. Koumaravelou</name><name sortKey="Krishnamoorthy, R" sort="Krishnamoorthy, R" uniqKey="Krishnamoorthy R" first="R." last="Krishnamoorthy">R. Krishnamoorthy</name><name sortKey="Tamouza, R" sort="Tamouza, R" uniqKey="Tamouza R" first="R." last="Tamouza">R. Tamouza</name><name sortKey="Tamouza, R" sort="Tamouza, R" uniqKey="Tamouza R" first="R." last="Tamouza">R. Tamouza</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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